|
T3479 |
(RS)-MCPG
|
alpha-MCPG,(±)-MCPG |
GluR
|
|
(RS)-MCPG ((±)-MCPG) is a non-selective group I/II metabotropic glutamate receptor antagonist. |
|
T9776 |
TRPM4 inhibitor 8
|
|
TRP/TRPV Channel
|
|
TRPM4 inhibitor 8 is an inhibitor of Transient receptor potential melastatin 4(TRPM4) which contributes to viability, migration, cell cycle shift, and adhesion. |
|
TQ0233 |
Traxoprodil
|
CP101606 |
NMDAR
,
iGluR
|
|
Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM). |
|
TP1380 |
Galanin (1-16), mouse, porcine, rat
|
|
Neuropeptide Y Receptor
|
|
Galanin (1-16), mouse, porcine, rat is a hippocampal galanin receptor agonist(Kd = 3 nM) with high biological activity on locus coeruleus neurons. |
|
T23782 |
Benzolamide
|
CL-11366,W 1803,CL 11366,CL11366,W-1803 |
Carbonic Anhydrase
|
|
Benzolamide (CL 11366) inhibits carbonic anhydrase effectively and low-threshold calcium currents in hippocampal pyramidal neurons. |
|
T72662 |
NMDAR/TRPM4-IN-2
|
|
ERK
,
TRP/TRPV Channel
,
NMDAR
,
iGluR
|
|
NMDAR/TRPM4-IN-2 is a potent interfacial inhibitor of NMDAR/TRPM4 interaction.NMDAR/TRPM4-IN-2 protects against MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss in mice.NMDAR/TRPM4-IN-2 has neuroprot... |
|
T17197 |
UCL 2077
|
|
|
|
UCL 2077 is a subtype-selective blocker of the epilepsy-associated KCNQ channels and it also is a selective slow-afterhyperpolarization channel blocker，with IC50 of 500 nM in hippocampal neurons in culture, having minima... |
|
TP1945L1 |
Pep2m, myristoylated acetate
|
Pep2m, myristoylated acetate(1423381-07-0 free base) |
PKC
|
|
Pep2m, myristoylated acetate is a Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protei... |
|
T41142 |
EM 163
|
|
IL Receptor
,
p38 MAPK
,
MyD88
|
|
EM 163 is a TIR-TIR interaction inhibitor, which is a TIR (Toll/interleukin-1 receptor) structural domain mimic of the MyD88 protein. EM 163 targets the TIR structural domain in the IL-1 receptor and blocks the interacti... |
|
T71977 |
Etiocholanedione
|
|
|
|
Etiocholanedione is a neurosteroid that inhibits glycine-induced chloride currents (IGly) in isolated rat hippocampal pyramidal neurons. |
|
T37162 |
8-hydroxy Efavirenz
|
|
|
|
8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz . 8-hydroxy Efavirenz is formed when efavirenz is metabolized by the cytochrome P450 (CYP) isoform CYP2B... |
|
TP1317 |
Galanin (1-16), mouse, porcine, rat TFA
|
|
|
|
Galanin (1-16), mouse, porcine, rat is an agonist of the hippocampal galanin receptor, with a Kd of 3 nM. Galanin (1-16), mouse, porcine, rat shows high biological activity on locus coeruleus neurons. |
|
T80980 |
Tityustoxin-Kα
|
TsTx-Kα |
|
|
Tityustoxin-Kα (TsTx-Kα) acts as an inhibitor of potassium voltage-gated channels, exhibiting a dose-dependent blockade of the sustained outward current in cultured hippocampal neurons [1]. |
|
T73099 |
Etbicyphat
|
Trimethylopropane phosphate |
|
|
Etbicyphat (Trimethylopropane phosphate), a potent competitive antagonist of GABA(A) receptors, binds to GABA(A)-benzodiazepine receptors and induces epileptiform activities in hippocampal CA1 neurons. |
|
T73094 |
Adhesamine
|
|
|
|
Adhesamine, a dumbbell-shaped molecule, plays a crucial role in activating the MAPK/FAK pathway, thus promoting mammalian cell adhesion and growth. Additionally, it accelerates the differentiation and enhances the surviv... |
|
T76288 |
GPR
|
|
|
|
GPR, a tripeptide, shows promise in Alzheimer's disease (AD) research by protecting cultured rat hippocampal neurons from amyloid-beta (Aβ)-induced death through the inhibition of caspase-3/p53-dependent apoptosis. |
|
TP1945 |
Pep2m, myristoylated
|
|
|
|
Cell-permeable, myristoylated form of pep2m. Peptide inhibitor of the interaction between the C-terminus of the GluA2 (AMPA receptor) subunit and N-ethylmaleimide-sensitive fusion protein (NSF), a protein that regulates ... |
|
T74195 |
4′-Demethylnobiletin
|
|
|
|
4′-Demethylnobiletin, a bioactive metabolite, activates the PKA/ERK/CREB signaling pathway, enhances CRE-mediated transcription in hippocampal neurons, and reverses memory impairment linked to NMDA receptor antagonism th... |
|
T82297 |
GluN1(356-385)
|
|
|
|
GluN1 (356-385) is an antigenic peptide implicated in N-methyl-D-aspartate receptor (NMDAR) encephalitis and has been shown to decrease the density of NMDAR surface clusters in hippocampal neurons. It serves as a tool to... |
|
T80171 |
Tamapin TFA
|
|
Potassium Channel
|
|
Tamapin TFA, a venom peptide isolated from the Indian red scorpion (Mesobuthus tamulus) [1], selectively targets and blocks small conductance Ca(2+)-activated K(+) (SK) channels, particularly the SK2 subtype (Potassium C... |
|
T36803 |
AAQ chloride
|
|
|
|
Photoswitchable Kv channel blocker (IC50 values are 2 and 64 μM at 500 nm and 380 nm respectively). Switches conformation from cis to trans at 500 nm and trans to cis at 380 nm. Exhibits minimal activity at Nav1.2 and L-... |
|
T36781 |
St-Ht31 P
|
st-Ht31 P |
|
|
Negative control for st-Ht31 .
Gorshkov et al (2017) AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nat.Chem.Biol. 13 425 PMID:28192412 |Vijayaraghavan et al (1997) Protein kinase A-a... |
|
T75958 |
β-Amyloid (22-35) (TFA)
|
|
|
|
β-Amyloid 22-35 (Amyloid β-Protein 22-35) TFA, a fragment comprising residues 22-35 of the β-amyloid protein, exhibits cytotoxicity towards cultured rat hippocampal neurons in serum-free media. It aggregates and forms ty... |
|
T82295 |
GluR23Y
|
|
|
|
GluR23Y, a biologically active peptide, was utilized in an ELISA-based cell-surface assay to assess insulin-stimulated endocytosis of native AMPA receptors in cultured hippocampal neurons. GluR23Y effectively inhibited t... |
|
T37215 |
5α,6β-Dihydroxycholestanol
|
|
|
|
5α,6β-Dihydroxycholestanol is an oxysterol metabolite of cholesterol formed from conversion of cholesterol epoxides by 5,6-epoxysterol hydrolase. It inhibits NMDA-mediated calcium influx in HEK293 cells expressing NR1/NR... |
|
T38389 |
Prostaglandin D2 Ethanolamide
|
Prostaglandin D2 Ethanolamide |
|
|
Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase. The ... |
|
T70174 |
Pirlindole-d4 HCl
|
|
|
|
Pirlindole-d4 is intended for use as an internal standard for the quantification of pirlindole by GC- or LC-MS. Pirlindole is a selective and reversible monoamine oxidase A (MAO-A) inhibitor. It is selective for MAO-A ov... |
|
T27051 |
CM-414
|
CM 414,CM414 |
|
|
CM-414 is a dual inhibitor of HDACs and PDE5 for the Treatment of Alzheimer’s Disease (IC50 values of 60 nM, 310 nM, 490 nM, 322 nM, and 91 nM against PDE5, HDAC1, HDAC2, HDAC3, and HDAC6, respectively). Chronic treatmen... |
|
T72227 |
PI3K/Akt/CREB activator 1
|
|
|
|
PI3K/Akt/CREB Activator 1 is a potent, orally active compound that acts as an activator for the PI3K/Akt/CREB pathway. It enhances neuronal proliferation, induces differentiation of Neuro-2a cells into neuron-like morpho... |
|
T70063 |
GYKI 52466 HCl
|
|
|
|
GYKI 52466 is an allosteric AMPA receptor antagonist. It selectively inhibits AMPA-induced inward currents (IC50 = 7.5 µM) over NMDA- or GABA-induced inward currents in primary rat hippocampal neurons at 50 µM but also i... |
|
T37388 |
Afizagabar
|
|
|
|
Afizagabar (S44819) is a first-in-class, competitive, and selective antagonist at the GABA-binding site of the α5-GABAAR, with an IC50 of 585 nM for α5β2γ2 and a Ki of 66 nM for α5β3γ2. Afizagabar enhances hippocampal sy... |
|
T38204 |
GAT229
|
|
|
|
GAT229 is a positive allosteric modulator of cannabinoid receptor 1 (CB1) and the S-(-) enantiomer of the CB1 modulator GAT211. It does not activate the receptor on its own but enhances the binding and activity of CB ago... |
|
T36521 |
Alaproclate (hydrochloride)
|
|
|
|
Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s =... |
|
T83727 |
Tat-NTS Peptide TFA
|
Tat-Nuclear Translocation Signal Peptide |
|
|
Tat-NTS peptide, a cell-penetrating compound, comprises the HIV-1 Tat protein transduction domain fused with a 10-amino acid sequence (residues 228-237) from the repeat III domain of annexin A1, serving as a nuclear tran... |
|
T83731 |
Tat-CBD3 TFA
|
|
|
|
Tat-CBD3 is a chemical compound inhibiting the interaction between the N-type voltage-gated calcium channel Cav2.2 and collapsin response mediator protein 2 (CRMP2), as well as the interaction between CRMP2 and the NMDA ... |
|
T35560 |
SAR502250
|
|
|
|
SAR502250 is a potent, selective, ATP-competitive, orally active, and brain-penetrant GSK3 inhibitor with a human GSK-3β IC50 value of 12 nM. It exhibits antidepressant-like activity and is being researched for potential... |
